Substituted isoquinolines and isoquinolinones as Rho kinase inhibitors

US8541449B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Oliver Plettenburg · Kelkheim, DE
• Katrin Lorenz · Frankfurt am Main, DE
• John Weston · Frankfurt am Main, DE
• Matthias Loehn · Frankfurt am Main, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Olivier Duclos · Paris, FR
• Frederic Jeannot · Paris, FR

Key dates

• Filing date: Jun 19, 2009
• Grant date: Sep 24, 2013
• Expiry date: Oct 28, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.