Immunosuppressant drug extraction reagent for immunoassays
US8541554B2 · kind B2 · utility
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37References
13Claims
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Key dates
| Filing date | Dec 29, 2010 |
| Grant date | Sep 24, 2013 |
| Priority date | — |
| Expiry date | Mar 12, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/141111
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent metal salt and water. The sample extracts resulting from use of each of these combinations have low vapor pressure and are compatible with immunochemistry assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.