Methods and compositions for CNS delivery of iduronate-2-sulfatase
US8545837B2 · kind B2 · utility
27Cited by
9References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 25, 2011 |
| Grant date | Oct 1, 2013 |
| Priority date | — |
| Expiry date | Jun 25, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/0019
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant for the treatment of Hunters Syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.