Methods and compositions for the treatment of cancers and pathogenic infections
US8545841B2 · kind B2 · utility
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Key dates
| Filing date | Jan 5, 2009 |
| Grant date | Oct 1, 2013 |
| Priority date | — |
| Expiry date | Aug 3, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject application provides small compounds that are able to suppress autophagy in various cells. These compounds are useful in augmenting the existing treatments of various cancers and microbial/parasitic infections. Thus, the subject application also provides methods of treating various types of cancers and microbial/parasitic infections. Also provided by the subject application are methods of suppressing the expansion of autophagosomes within cells or individuals and inhibiting the lipidation of autophagy-related protein 8 (Atg8).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.