Orally disintegrating tablets and methods of manufacture
US8545881B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 19, 2004 |
| Grant date | Oct 1, 2013 |
| Priority date | — |
| Expiry date | Apr 3, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/4045
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A tablet that rapidly disintegrates in the oral cavity comprising a compressed blend of rapidly dispersing microgranules prepared by granulating a sugar alcohol or a saccharide or a mixture thereof having an average particle size less than about 30 microns and a disintegrant, and a taste-masked microcapsule containing at least one drug, the microcapsule being prepared by granulating a pharmaceutically acceptable formulation comprising at least one drug in a therapeutically effective amount and at least one polymeric binder that improves resilience of the microgranules, wet milling the granulated mass, and microencapsulating the milled granules to provide microcapsules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.