Method for identifying a non-anticoagulant sulfated polysaccharide which enhances blood coagulation dependence on FXI
US8546096B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Aug 21, 2009 |
| Grant date | Oct 1, 2013 |
| Priority date | — |
| Expiry date | Jul 21, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/86
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of identifying a non-anticoagulant sulfated polysaccharide (NASP) which is capable of enhancing blood coagulation in dependence of FXI, the method comprising: a) combining a blood or plasma sample having activation competent FXI with a sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample; b) combining a corresponding blood or plasma sample deficient In activation competent FXI with a sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample and c) comparing the clotting or thrombin generation parameters of the blood or plasma samples as determined in steps (a) and (b) with each other.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.