Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester

US8546112B2 · kind B2 · utility

Assignee

• Sandoz AG · CH

Inventors

• Martin Albert · Brixlegg, AT
• Ferdinand Zepeck · Kundl, AT
• Andreas Berger · Ebbs, AT
• Waander Riethorst · Brixlegg, AT
• Helmut Schwab · Graz, AT
• Daniel Luschnig · Graz, AT
• Peter Remler · Graz, AT
• Joerg Salchenegger · Kundl, AT
• Doris Osl · Kundl, AT
• Dominic De Souza · Regau, AT

Key dates

• Filing date: May 19, 2009
• Grant date: Oct 1, 2013
• Expiry date: Nov 26, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid ester and its salts. Also disclosed are processes for the preparation of 5-methyl-3-nitromethyl-hexanoic acid salt and a process for the preparation of 3-(aminomethyl)-5-methylhexanoic acid. (S)-5-Methyl-3-nitromethyl-hexanoic acid or (R)-5-methyl-3-nitromethyl-hexanoic acid in enantioenriched form or enantiopure form as well as salts thereof, (S)-5-methyl-3-nitromethyl-hexanoic acid ester or (R)-5-methyl-3-nitromethyl-hexanoic acid ester in enantioenriched form or enantiopure form and a compound, namely Formula (XIII), in racemic form, enantioenriched form or enantiopure form are also disclosed.