Method and device for forming a three-dimensional arrangement of biological cells

US8546117B2 · kind B2 · utility

Assignee

• Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V. · DE

Inventors

• Charli Kruse · Herrnburg, DE
• Philipp Ciba · Stade, DE
• Guenter R. Fuhr · Berlin, DE

Key dates

• Filing date: Jun 6, 2008
• Grant date: Oct 1, 2013
• Expiry date: Feb 28, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/30
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method for forming a three-dimensional cell arrangement (1) of biological cells is disclosed, including the steps of preparation of the cell arrangement (1) on a flexible substrate (10) and deformation of the substrate (10), wherein the deformation of the substrate (10) is brought about by an attractive force exerted by the cells (2) on the substrate (10). A substrate (10), is also disclosed, made from a flexible material and including a substrate surface (11) for adhesion of a cell arrangement (1) of biological cells, wherein the substrate surface (11) has a number of force attachment points arranged to exert an attraction force which may be transmitted from the cells to the substrate (10) and the substrate (10) has a flexibility such that the substrate (10) is deformable with the action of the attraction force.