Bicyclic aryl sphingosine 1-phosphate analogs

US8546359B2 · kind B2 · utility

Assignee

• BIOGEN IDEC MA INC. · US

Inventors

• Richard D. Caldwell · Melrose, US
• Kevin M. Guckian · Northborough, US
• Gnanasambandam Kumaravel · Westford, US
• Wen-Cherng Lee · Lexington, US
• Edward Yin-Shiang Lin · Ashland, US
• Xiaogao Liu · Dover, US
• Bin Ma · Arlington, US
• Daniel Scott · Weston, US
• Zhan Shi · Concord, US
• Jermaine Thomas · Chelsea, US
• Arthur G. Taveras · Rockaway, US
• Guo Zhu Zheng · Lexington, US

Key dates

• Filing date: Sep 10, 2012
• Grant date: Oct 1, 2013
• Expiry date: Sep 10, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65744
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors.