Chiral fused [1,2]imidazo[4,5-c] ring compounds

US8546383B2 · kind B2 · utility

Assignee

• 3M INNOVATIVE PROPERTIES COMPANY · US

Inventors

• George W. Griesgraber · Eagan, US
• Tushar A. Kshirsagar · Woodbury, US
• Azim A. Celebi · Burlingame, US
• Sarah J. Slania · Eagan, US
• Michael E. Danielson · Windom, US
• Michael J. Rice · Oakdale, US
• Joshua R. Wurst · North St. Paul, US

Key dates

• Filing date: May 25, 2012
• Grant date: Oct 1, 2013
• Expiry date: May 25, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a —CH(—X1—R1)— group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.