Heterocyclic compounds as metap-2 inhibitors

US8546406B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Timo Heinrich · Groß-Umstadt, DE
• Frank Zenke · Darmstadt, DE
• Mireille Krier · Mühltal, DE
• Kai Schiemann · Darmstadt, DE

Key dates

• Filing date: Dec 22, 2009
• Grant date: Oct 1, 2013
• Expiry date: Dec 27, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I, in which D, X, Y, Z, R and R1 have the meanings indicated in Claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumors.