Process for the manufacture of persilylated peptides

US8546530B2 · kind B2 · utility

Assignee

• SOLVAY (Société Anonyme) · BE

Inventors

• Roland Callens · Grimbergen, BE
• Thierry Delplanche · Court-Saint-Etienne, BE

Key dates

• Filing date: Nov 18, 2008
• Grant date: Oct 1, 2013
• Expiry date: Nov 25, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Process for the manufacture of a peptide or peptide analog, which comprises (a) producing a persilylated peptide or persilylated peptide analogue by silylating a corresponding peptide by reaction with a silylating agent other than trimethylsilylcyanide, and (b) reacting a compound of formula (I) X-A-COOH wherein X is an amino protecting group, A is an amino acid, peptide or peptide analogue residue, and —COOH designates an optionally activated carboxylic group, with a persilylated peptide or a persilylated peptide analogue containing from 4 to 15 amino acids.