NIP thiazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydroge-nase-1
US8546575B2 · kind B2 · utility
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Key dates
| Filing date | Apr 8, 2009 |
| Grant date | Oct 1, 2013 |
| Priority date | — |
| Expiry date | Jan 6, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to NIP thiazole derivatives of formula (I) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.