Iodonium Cyclophanes for SECURE arene functionalization
US8546578B2 · kind B2 · utility
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Key dates
| Filing date | Feb 4, 2011 |
| Grant date | Oct 1, 2013 |
| Priority date | — |
| Expiry date | Apr 6, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J1/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This disclosure relates to compounds, reagents, and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18F labeled radiotracers. For example, this disclosure provides universal “locked” aryl substituents that result in StereoElectronic Control of Unidirectional Reductive Elimination (SECURE) from diaryliodonium salts. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.