Replenishment and enrichment of ocular surface lubrication

US8551467B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• The Schepens Eye Research Institute, Inc. · US

Inventors

• Benjamin Sullivan · San Diego, US
• Tannin A. Schmidt · Calgary, CA
• David A. Sullivan · Boston, US

Key dates

• Filing date: Jul 2, 2012
• Grant date: Oct 8, 2013
• Expiry date: Jul 2, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P27/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An ophthalmic composition, and methods of use thereof, including for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface or for the treatment or care of ophthalmic devices. The ophthalmic composition comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The ophthalmic composition may also comprise one or more ophthalmically acceptable agents.