Patent · US Active

Rubella E1 envelope protein variants and their use in detection of anti-rubella antibodies

US8551696B2 · kind B2 · utility

0Cited by

1References

7Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Christian Scholz · Penzberg, DE
Ralf Bollhagen · Penzberg, DE
Alfred Engel · Tutzing, DE
Elke Faatz · Huglfing, DE
Peter Schaarschmidt · Ulm, DE
Barbara Upmeier · Iffeldorf, DE
Toralf Zarnt · Penzberg, DE

Key dates

Filing date	Jun 3, 2010
Grant date	Oct 8, 2013
Priority date	—
Expiry date	Nov 5, 2031

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention relates to soluble rubella E1 antigens and variants of these antigens. The antigens contain amino acids 201 to 432 or 169 to 432 and are lacking amino acids 453 to 481 as well as at least the amino acids 143 to 164. They further contain a region spanning two disulfide-bridges. The invention also relates to a recombinant DNA molecule encoding the rubella E1 antigens, the expression of rubella E1 antigens as chaperone fusion proteins and their use in a method of detecting antibodies against rubella in a sample.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.