Methods for promoting HSC engraftment
US8551782B2 · kind B2 · utility
6Cited by
3References
9Claims
0Family size
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Key dates
| Filing date | Mar 27, 2012 |
| Grant date | Oct 8, 2013 |
| Priority date | — |
| Expiry date | Mar 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.