Anti-viral pyrimidine nucleoside analogues

US8551965B2 · kind B2 · utility

Assignees

• University College Cardiff Consultants Limited · GB
• Rega Foundation · BE

Inventors

• Christopher McGuigan · Cardiff, GB
• Jan Balzarini · Heverlee, BE

Key dates

• Filing date: Sep 24, 2010
• Grant date: Oct 8, 2013
• Expiry date: Sep 24, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/23
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; R8 and R9 can be hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, or aryl; Q can be O, S or CY2, where Y may be H, alkyl or halogens; X can be O, NH, S, N-alkyl, (CHR2)m where m is 1 to 10, and CY2; Z can be O, S, NH, or N-alkyl; U″ is H and U′ can be H or CH2; wherein: T can be OH, H, halogens, O-alkyl, O-acyl, O-aryl, CN, NH2. or N3; T′ and T″ can be H or halogen; and W can be H or a phosphate group. Compounds show anti-viral activity, for example with respect to varicella zoster virus.