(S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-4-(4-fluorobenzoyl)-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl)-2-methylamino-propionamide, or pharmaceutically acceptable salts thereof and their uses

US8552003B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Mark G. Charest · Montgomery, US
• Christine Hiu-Tung Chen · Waltham, US
• Zhuoliang Chen · Cambridge, US
• Miao Dai · Shanghai, CN
• Feng He · Nanhu, CN
• Huangshu Lei · Ann Arbor, US
• Ly Pham · Ann Arbor, US
• Sushil Sharma · East Hanover, US
• Christopher Sean Straub · Cambridge, US
• Run-Ming David Wang · Cambridge, US
• Fan Yang · Brookline, US
• Leigh Zawel · Bowie, US

Key dates

• Filing date: Jul 31, 2007
• Grant date: Oct 8, 2013
• Expiry date: May 13, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06191
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a compound of the formula:or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.