Patent · US Active

Substituted tricyclic compounds as protein kinase inhibitors

US8552018B2 · kind B2 · utility

7Cited by

8References

7Claims

0Family size

Assignees

Inventors

Laurence Hurley · Austin, US
Daruka Mahadevan · Tucson, US
David J. Bearss · Alpine, US
Hariprasad Vankayalapati · Draper, US
Sridevi Bashyam · Bengaluru, IN
Steven L. Warner · Sandy, US
James Welsh · Oro Valley, US

Key dates

Filing date	Mar 18, 2011
Grant date	Oct 8, 2013
Priority date	—
Expiry date	Mar 18, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D495/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from:and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.