Polypeptides and use thereof

US8552149B2 · kind B2 · utility

Assignee

• ALLIGATOR BIOSCIENCE AB · SE

Inventors

• Christina Furebring · Lund, SE
• Anna Rosén · Austin, US
• Karin Haraldsson · Lund, SE
• Erika Gustafsson · Bjärred, SE
• Björn Walse · Lund, SE

Key dates

• Filing date: Nov 30, 2009
• Grant date: Oct 8, 2013
• Expiry date: Nov 30, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 2, or a fragment or variant thereof having a biological activity of CHIPS, wherein the fragment or variant retains amino acid substitutions K40E, D42V, N77H, K100R, K105R, N111 K and/or G112A relative to the wildtype CHIPS protein of SEQ ID NO:1. In one embodiment, polypeptide consists of the amino acid sequence of SEQ ID NO: 2. Related aspects of the invention provide pharmaceutical compositions comprising a polypeptide of the invention, together with methods or making and using the same.