Method and apparatus for providing pulses inhalation of 17O2 for magnetic resonance imaging of cerebral metabolism
US8554305B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 18, 2008 |
| Grant date | Oct 8, 2013 |
| Priority date | — |
| Expiry date | Mar 30, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/7207
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Prior approaches have delivered 17O2 to a subject by inhalation, but the relationship between local signal changes and metabolism has been complicated by H217O created in non-cerebral tissues. During a brief pulse of 17O2 inhalation, this arterial input function for H217O is negligible due to convective transport delays. Additional delays in the arterial input function due to restricted diffusion of water makes pulsed inhalation of 17O2 even more effective. Accordingly, ventilator system are provided to deliver 17O2 as a brief pulse to a subject. Subsequent MR imaging demonstrates delayed appearance of H217O in the cerebral ventricles, suggesting that the arterial input function of H217O is delayed by restricted water diffusion in addition to convective transit delays. Delivery as a brief pulse therefore offers significant advantages in relating MR signal changes directly to metabolism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.