Toll like receptor 4 dysfunction and the biological applications thereof
US8557517B2 · kind B2 · utility
4Cited by
0References
30Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 17, 2007 |
| Grant date | Oct 15, 2013 |
| Priority date | — |
| Expiry date | Nov 15, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/136
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to an in vitro method of assessing the sensitivity of a subject to a treatment of cancer, which method comprises detecting the presence of a mutated Toll Like Receptor 4 (TLR4) nucleic acid or an abnormal TLR4 protein expression or activity in a sample from the subject, the presence of said mutated TLR4 nucleic acid or abnormal TLR4 expression or activity being indicative of a resistance to said treatment. The invention further provides compounds for treating or preventing a cancer in a subject having a mutated TLR4 nucleic acid or an abnormal TLR4 protein expression or activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.