Composite metastasis score with weighted coefficients for predicting breast cancer metastasis, and uses thereof
US8557525B1 · kind B1 · utility
1Cited by
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26Claims
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Key dates
| Filing date | Feb 27, 2012 |
| Grant date | Oct 15, 2013 |
| Priority date | — |
| Expiry date | Feb 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a composite metastasis score (“cMS”) based on expression of a 14-gene molecular signature (referred to as a metastasis score, or “MS”) in combination with progesterone receptor (PR) expression that is useful for predicting breast cancer metastasis. In preferred embodiments, the cMS is determined by applying weighted coefficients to MS and PR. The present invention provides methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level information for predicting risk of breast cancer metastasis, among other embodiments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.