Spatially-defined macrocycles incorporating peptide bond surrogates
US8557765B2 · kind B2 · utility
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2Claims
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Key dates
| Filing date | May 26, 2009 |
| Grant date | Oct 15, 2013 |
| Priority date | — |
| Expiry date | Jul 22, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0802
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.