Homodimer of insulinotropic peptide analogues and method for preparation thereof and use thereof
US8557771B2 · kind B2 · utility
20Cited by
0References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 15, 2010 |
| Grant date | Oct 15, 2013 |
| Priority date | — |
| Expiry date | Mar 15, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a homodimer of insulinotropic peptide analogues and method for preparation thereof and use thereof, wherein the insulinotropic peptide analogue comprises GLP-1 and Exendin-4. The homodimer of insulinotropic peptide analogues of the invention is made by conjugating two identical insulinotropic peptide analogue molecules at the C-terminal Cys residues via disulfide bond or PEG molecule. The homodimer of insulinotropic peptide analogues of the invention has superior stability and biological activity in vivo, and prolonged half-life in the circulation, and can be used for the preparation of hypoglycemic drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.