Patent · US Active

Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof

US8557812B2 · kind B2 · utility

5Cited by

7References

7Claims

0Family size

Assignee

THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

Shaomeng Wang · Saline, US
Guoping Wang · Naperville, US
Guozhi Tang · Shanghai, CN
Renxiao Wang · Ann Arbor, US
Zaneta Nikolovska-Coleska · Ann Arbor, US
Dajun Yang · Suzhou, CN
Liang Xu · Ann Arbor, US

Key dates

Filing date	Aug 22, 2005
Grant date	Oct 15, 2013
Priority date	—
Expiry date	Jan 3, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2603/74
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.