Cocaine analogs and methods of preparation and uses thereof

US8557842B2 · kind B2 · utility

Assignee

• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• Franklin Davis · Newton, US
• Naresh Theddu · Darsi, IN
• Maarten E. A. Reith · New York, US

Key dates

• Filing date: May 18, 2012
• Grant date: Oct 15, 2013
• Expiry date: May 18, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel cocaine analogs. The invention also provides a method of preparing cocaine analogs with control over the substituents installed at the C-1, C-2, C-3, C-4 and N-8 positions of the tropane bicyclic scaffold. The invention further provides methods of providing anesthesia, blocking reuptake of a monoamine neurotransmitter, and treating depression, by administering to a subject in need of such treatment a pharmaceutical composition comprising a compound of the invention.