Process for preparing enantiomerically pure indolopyridines

US8557991B2 · kind B2 · utility

Assignee

• 4SC AG · DE

Inventors

• Bernd Muller · Flintbek, DE
• Helmut Schlemper · Radolfzell, DE

Key dates

• Filing date: Mar 5, 2009
• Grant date: Oct 15, 2013
• Expiry date: Dec 7, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a novel process for the preparation of pharmacologically interesting indolopyridine derivatives containing tetracyclic tetrahydro-11-carboline-hydantoines linked to a basic side chain and the corresponding salts, which can be used as Eg5 inhibitors, with very high overall chemical yield and enantiomeric purity.