Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof

US8562945B2 · kind B2 · utility

Assignee

• Molecular Insight Pharmaceuticals, Inc. · US

Inventors

• John W. Babich · Cambridge, US
• Craig Zimmerman · Topsfield, US
• John Joyal · Melrose, US
• Kevin P. Maresca · Tewksbury, US
• John Marquis · Nashua, US
• Genliang Lu · Winchester, US
• Jian Wang · Shanghai, CN
• Shawn Hillier · Danvers, US

Key dates

• Filing date: Dec 4, 2009
• Grant date: Oct 22, 2013
• Expiry date: Sep 18, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F13/005
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin.