End-modified poly(beta-amino esters) and uses thereof

US8562966B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Gregory T. Zugates · Chelmsford, US
• Andreas Zumbuehl · Nyon, CH
• Robert S. Langer · Newton, US
• Daniel Griffith Anderson · Framingham, US

Key dates

• Filing date: Dec 6, 2011
• Grant date: Oct 22, 2013
• Expiry date: Dec 6, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08L79/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.