Patent · US Active

Stable digestive enzyme compositions

US8562981B2 · kind B2 · utility

8Cited by

25References

15Claims

0Family size

Assignee

Aptalis Pharma Limited · IE

Inventors

Giovanni Ortenzi · Monza, IT
Marco Marconi · Cinisello Balsamo, IT
Luigi Mapelli · Milano, IT

Key dates

Filing date	Feb 2, 2011
Grant date	Oct 22, 2013
Priority date	—
Expiry date	Feb 2, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K9/2866
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.