Methods for treating GI syndrome and graft versus host disease
US8562993B2 · kind B2 · utility
3Cited by
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6Claims
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Key dates
| Filing date | May 6, 2008 |
| Grant date | Oct 22, 2013 |
| Priority date | — |
| Expiry date | Sep 6, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
We have discovered that administering anti-ceramide antibody treats and prevents an array of diseases mediated by cytolytic T lymphocyte (CTLs)-induced killing and by damage to endothelial microvasculture, including radiation-induced GI syndrome, Graft vs. Host diseases, inflammatory diseases and autoimmune diseases. We have also discovered new anti-ceramide monoclonal antibodies, that have therapeutic use preferably in humanized form to treat or prevent these diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.