Mutational profiles in HIV-1 reverse transcriptase correlated with phenotypic drug resistance
US8563236B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 13, 2009 |
| Grant date | Oct 22, 2013 |
| Priority date | — |
| Expiry date | May 25, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/912
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to phenotypic interpretation in order to correlate virus mutational profiles with drug resistance. The invention also relates to methods of utilizing the mutational profiles of the invention in databases, drug development, i.e., drug design, and drug modification, therapy and treatment design, clinical management and diagnostic analysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.