Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease severity
US8563257B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 12, 2009 |
| Grant date | Oct 22, 2013 |
| Priority date | — |
| Expiry date | Jun 30, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6883
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.