Convergent synthesis of renin inhibitors and intermediates useful therein
US8563279B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Dec 19, 2008 |
| Grant date | Oct 22, 2013 |
| Priority date | — |
| Expiry date | Jan 6, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C36 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.