Aminopyrimidine kinase inhibitors

US8563539B2 · kind B2 · utility

Assignee

• Jasco Pharmaceuticals, LLC · US

Inventors

• Carmen M. Baldino · Woburn, US
• Justin L. Caserta · Billerica, US
• Chee-Seng Lee · Somerville, US
• Robert Nicewonger · Tyngsborough, US
• Yvonne L. Flanders · Medford, US
• Stephane Dumas · Cambridge, US

Key dates

• Filing date: Dec 23, 2010
• Grant date: Oct 22, 2013
• Expiry date: Nov 6, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., CK1γ), casein kinase 2 (CK2), Pim 1, Pim2, Pim3, the TGFβ pathway, the Wnt pathway, the JAK/STAT pathway, and/or the mTOR pathway.