Beta-lactones as antibacterial agents

US8563598B2 · kind B2 · utility

Assignee

• Ludwig-Maximilians-Universitat Munchen · DE

Inventors

• Stephan Sieber · Marburg, DE
• Thomas Böttcher · Maisach, DE

Key dates

• Filing date: Feb 4, 2009
• Grant date: Oct 22, 2013
• Expiry date: Jun 26, 2029

Classification

• Technology area (CPC —): General

Abstract

The present invention relates to specific beta-lactone compounds and compositions thereof for the treatment of infections, such as, e.g., infections with bacteria or infections with protozoa, in particular infections with Gram-positive and/or Gram-negative bacteria and of infectious diseases caused by or related to Gram-positive and/or Gram-negative bacteria, and to the modulation of virulence of Gram-positive and/or Gram-negative bacteria or of protozoa by specific beta-lactone compounds. The invention further relates to the use of the compounds or compositions for preventing or eliminating biofilms.