Methods for synthesizing glycinols, glyceollins I and II, compositions of selected intermediates, and therapeutic uses thereof

US8563599B2 · kind B2 · utility

Assignees

• THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF AGRICULTURE · US
• Xavier University of Louisiana · US
• The University of Toledo · US

Inventors

• Paul W. Erhardt · Toledo, US
• Rahul Khupse · Toledo, US
• Jefferey G. Sarver · Toledo, US
• Thomas Cleveland · San Diego, US
• Stephen M. Boue · New Orleans, US
• Thomas E. Wiese · New Orleans, US
• Matthew E. Burow · New Orleans, US
• John A. McLachlan · New Orleans, US

Key dates

• Filing date: Mar 3, 2009
• Grant date: Oct 22, 2013
• Expiry date: Apr 15, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.