Lysosomal targeting peptides and uses thereof
US8563691B2 · kind B2 · utility
6Cited by
71References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 17, 2012 |
| Grant date | Oct 22, 2013 |
| Priority date | — |
| Expiry date | Feb 17, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides further improved compositions and methods for efficient lysosomal targeting based on the GILT technology. Among other things, the present invention provides methods and compositions for targeting lysosomal enzymes to lysosomes using furin-resistant lysosomal targeting peptides. The present invention also provides methods and compositions for targeting lysosomal enzymes to lysosomes using a lysosomal targeting peptide that has reduced or diminished binding affinity for the insulin receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.