Peptide aptamer for neutralizing the binding of platelet antigen specific antibodies and diagnostic and therapeutic applications containing the same
US8563704B2 · kind B2 · utility
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Key dates
| Filing date | Apr 18, 2012 |
| Grant date | Oct 22, 2013 |
| Priority date | — |
| Expiry date | Apr 18, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/222
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a peptide aptamer which mimics particularly the human platelet antigen HPA-Ia epitope present on the platelet GPIIb/IIIa molecules and which is capable of neutralizing the binding of HPA-I a specific antibodies (anti-HPA-1 a). This peptide aptamer is advantageously used in a method for detecting and identifying HPA-I a specific antibodies in human serum, in a diagnostic kit for screening and identifying antibodies, in an immunoassay and a pharmaceutical composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.