Morphinan derivatives and preparation methods thereof
US8563721B2 · kind B2 · utility
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3References
18Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 19, 2009 |
| Grant date | Oct 22, 2013 |
| Priority date | — |
| Expiry date | Feb 14, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/09
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.