Preparation of saturated ketone morphinan compounds having low metal content
US8563725B2 · kind B2 · utility
1Cited by
3References
16Claims
0Family size
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Key dates
| Filing date | Apr 26, 2011 |
| Grant date | Oct 22, 2013 |
| Priority date | — |
| Expiry date | Feb 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides processes for the preparation of saturated ketone morphinan compounds from a morphinan comprising an allyl alcohol ring moiety, wherein the final product has a low metal content. In particular, the invention provides processes that utilize isomerization reactions catalyzed by transition metal catalysts and the subsequent removal of the transition metal using metal scavengers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.