Patent · US Active

Process for the preparation of (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates

US8563775B2 · kind B2 · utility

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3References

4Claims

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Assignee

LABORATORIO CHIMICO INTERNAZIONALE S.P.A. · IT

Inventors

Annibale Salvi · Milano, IT
Antonio Nardi · Gambellara, IT
Bruno De Angelis · Segrate, IT

Key dates

Filing date	Jun 6, 2007
Grant date	Oct 22, 2013
Priority date	—
Expiry date	Aug 10, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C233/05
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

This invention relates to the preparation of (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic acid into biologically active molecules such as pregabalin.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.