Automated system and method for monitoring chromatography column performance, and applications thereof
US8568586B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 2009 |
| Grant date | Oct 29, 2013 |
| Priority date | — |
| Expiry date | Feb 6, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/889
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides automated systems and methods for monitoring column performance in process chromatography, and applications thereof. In an embodiment, column performance is monitored by generating a plurality of process values such as, for example, conductivity values or pH values with a detector during a chromatography step transition between a first mobile phase liquid and a second mobile phase liquid. The process values are transformed to form transformed process values in which noise present in the process values is suppressed. Column performance parameters are calculated based on the transformed process values and displayed during movement of the second mobile phase liquid through the chromatography column. The displayed performance parameters enable an operator to make a determination, for example, regarding the quality of the chromatography column packing and whether to continue the chromatography process or stop the chromatography process until the chromatography column can be repacked or replaced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.