Screening methods using G-protein coupled receptors and related compositions
US8568737B2 · kind B2 · utility
2Cited by
93References
9Claims
0Family size
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Key dates
| Filing date | Aug 1, 2008 |
| Grant date | Oct 29, 2013 |
| Priority date | — |
| Expiry date | Feb 9, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/726
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a G-protein is correlated with the length of time over which the agonist is effective, independently of its pharmacokinetic properties. The invention also provides PTH- and PTHrP-derived polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.