Patent · US Active

Detection of post-translationally modified peptides with liquid crystals

US8569043B2 · kind B2 · utility

0Cited by

28References

14Claims

0Family size

Assignee

Wisconsin Alumni Research Foundation · US

Inventors

Nicholas Abbott · Madison, US
Brian H. Clare · Madison, US
Paul J. Bertics · Oregon, US

Key dates

Filing date	Jul 15, 2010
Grant date	Oct 29, 2013
Priority date	—
Expiry date	Jun 12, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC40B60/14
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

A method for differentiating between a post-translationally modified peptide and a peptide contained in a sample, comprising: (a) contacting the sample with a peptide attachment surface to create a peptidized surface, wherein the sample includes at least one functional group; (b) contacting the peptidized surface with a recognition reagent that selectively binds or forms a complex with the post-translationally modified peptide in the sample to provide an incubated surface; and (c) contacting a liquid crystal with the incubated surface and detecting presence of post-translationally modified peptide in the sample with the liquid crystal.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.