Patent · US Active

Stabilized fibronectin domain compositions, methods and uses

US8569227B2 · kind B2 · utility

22Cited by
16References
4Claims
0Family size

Assignee

Inventor

Key dates

Filing dateApr 29, 2011
Grant dateOct 29, 2013
Priority date—
Expiry dateAug 15, 2031

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2318/20
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof, exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.