Adenosine analogs and their use

US8569259B2 · kind B2 · utility

Assignee

• MICRODOSE THERAPEUTX, INC. · US

Inventors

• Efrat Ben-Zeev · Kiryat Motzkin, IL
• Vincent Jacques · Somerville, US
• Yael Marantz · Even Yehuda, IL
• A. Sekar Reddy · Burlington, US
• Zhaoda Zhang · Andover, US
• Oren Becker · Mevaseret Tsiyon, IL
• Dilara McCauley · Cambridge, US
• Pini Orbach · Tel Mond, IL
• Sharon Shacham · Gdera, IL
• Ashis Saha · Stow, US
• Michael Xie · Natick, US

Key dates

• Filing date: Nov 16, 2007
• Grant date: Oct 29, 2013
• Expiry date: Mar 7, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.