Carboxamide compounds and their use

US8569282B2 · kind B2 · utility

Assignee

• CytoPathfinder, Inc. · JP

Inventors

• Efrat Ben-Zeev · Kiryat Motzkin, IL
• Dongli Chen · Sharon, US
• Merav Fichman · Lod, IL
• Shomir Ghosh · Brookline, US
• Steffi Koerner · Medford, US
• Jian Lin · Watertown, US
• Yael Marantz · Even Yehuda, IL
• Rosa E. Melendez · Toronto, CA
• Pradyumna Mohanty · Woburn, US
• Sharon Shacham · Gdera, IL
• Zhaoda Zhang · Andover, US

Key dates

• Filing date: Dec 11, 2008
• Grant date: Oct 29, 2013
• Expiry date: May 25, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.